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Archive for April, 2011

I have been swamped for the last week or so with the day job and have just started my workshop intensive for my nutrition therapy class … so a few more days of light blogging.

But oh happy day … Stephan Guyenet has begun his series of posts on the implications of a “body fat setpoint”, starting with Food Reward: a Dominant Factor in Obesity, Part I (emphasis mine):

The human brain evolved to deal with a certain range of rewarding experiences. It didn’t evolve to constructively manage strong drugs of abuse such as heroin and crack cocaine, which overstimulate reward pathways, leading to the pathological drug seeking behaviors we call addiction. These drugs are “superstimuli” that exceed our reward system’s normal operating parameters. Over the next few posts, I’ll try to convince you that in a similar manner, industrially processed food, which has been professionally crafted to maximize its rewarding properties, is a superstimulus that exceeds the brain’s normal operating parameters, leading to an increase in the body fat setpoint and other negative consequences.

This is going to be an important piece of the puzzle that folks like Taubes and the Drs Eades and others who look primarily at macronutrient ratios and insulin are missing IMO. It’s not just about fat storage hormones, but about appetite-regulating ones. And there are many more at play than just insulin or leptin.

This is gonna be good!

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I was watching the lectures on essential fatty acids for my nutrition class last week, and learned something that for me was a major, Oprah-league, a ha!

High levels of insulin (which you might have if you eat a traditional Western diet and have insulin resistance) increases delta-5 desaturase. So what?

Well, it turns out that delta-5 desaturase helps convert DGLA — an omega 6 fatty acid derived from the linoleic acid in grain/vegetable oils — into arachidonic acid or AA (see below; click image for larger version).

Western diet = inflammation + munchies

(more…)

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tweet map

Fun tool lets you explore word maps of tweets.

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I love, love, love Whole Health Source … it’s one of my top 3 favorite blogs. But today it’s almost love/hate (just kidding!) as Stephan teases readers with the prospect of his “simple new idea” to enable “the body to naturally return to a lower fat mass.”

Oh, do tell!

But there’s a great nugget in this post too. He highlights Arya Sharma’s recent UW Science in Medicine lecture analogy on why “eat less, move more” is an inadequate strategy:

[Dr. Sharma] spent a little bit of time pointing out the fallacy behind conventional obesity treatment. He used the analogy of edema, which is an abnormal accumulation of fluid in the body.

Since we know that the amount of fluid contained in the body depends on the amount of fluid entering the body and the amount of fluid leaving the body, the treatment for edema is obvious: drink less, pee more.

Of course, this makes no sense. It doesn’t address the underlying cause of edema and it will not help the patient. Yet we apply that exact same logic to fat loss. Since the amount of energy contained in the body (in the form of fat) depends on the amount entering and the amount leaving, the solution is easy: eat less, move more. Well, yes, if you can stick to that program it will cause fat loss. But that’s equivalent to telling someone with edema to drink less water. It will cause a loss of fluid, but it won’t correct the underlying problem that caused excessive fluid retention in the first place.

Nightmare on ELMM St indeed! I’m looking forward to his future posts.

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Quote of the day

Dr. Gene-Jack Wang, chair of medical research at Brookhaven National Laboratory, in CNN’s Why isn’t there a safe weight-loss pill?

We might not have any magic bullet. We might have to use a bomb.

Interesting read. I’m cautiously optimistic the right food can help.

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LOLcat photo
Made me laugh!

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Annoyed woman So I just saw a blurb about this study from this month’s American Journal of Clinical Nutrition:

Design: Men (n = 16) aged 22 ± 1 y (mean ± SE) were randomly assigned to 5 d of a high-fat, low-carbohydrate diet containing 75 ± 1% of calorie intake through fat consumption or to an isocaloric standard diet providing 23 ± 1% of calorie intake as fat. In a crossover design, subjects undertook the alternate diet after a 2-wk washout period, with results compared after the diet periods. …

Results: Compared with the standard diet, subjects who consumed the high-fat, low-carbohydrate diet had 44% higher plasma free fatty acids (P < 0.05), 9% lower cardiac PCr/ATP (P < 0.01), and no change in cardiac function. Cognitive tests showed impaired attention (P < 0.01), speed (P < 0.001), and mood (P < 0.01) after the high-fat, low-carbohydrate diet.

Conclusion: Raising plasma free fatty acids decreased myocardial PCr/ATP and reduced cognition, which suggests that a high-fat diet is detrimental to heart and brain in healthy subjects.

Really Oxford researchers? I guess they’ve never heard of induction flu, the temporary “mental fuzziness, fog and fatigue” many folks experience when initially going low-carb.

Here’s my lay take: if you want to test the response to a high fat diet, let the subjects acclimate to it first!

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